Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin

被引：295

作者：

Aspholm-Hurtig, M

Dailide, G

Lahmann, M

Kalia, A

Ilver, D

Roche, N

Vikström, S

Sjöström, R

Lindén, S

Bäckström, A

Lundberg, C

Arnqvist, A

Mahdavi, J

Nilsson, UJ

Velapatiño, B

Gilman, RH

Gerhard, M

Alarcon, T

López-Brea, M

Nakazawa, T

Fox, JG

Correa, P

Dominguez-Bello, MG

Perez-Perez, GI

Blaser, MJ

Normark, S

Carlstedt, I

Oscarson, S

Teneberg, S ^{[1
]}

Berg, DE

Borén, T

机构：

[1] Univ Gothenburg, Inst Med Biochem, SE-40530 Gothenburg, Sweden

[2] Umea Univ, Dept Odontol, Sect Oral Microbiol, SE-90187 Umea, Sweden

[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[4] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

[5] Lund Univ, Dept Cell & Mol Biol, SE-22184 Lund, Sweden

[6] Umea Univ, Dept Mol Biol, SE-90187 Umea, Sweden

[7] Lund Univ, SE-22100 Lund, Sweden

[8] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru

[9] Tech Univ Munich, Klinikum Rechts Isar, Dept Med, DE-81675 Munich, Germany

[10] Hosp Princesa, Dept Microbiol, Madrid 28006, Spain

[11] Yamaguchi Univ, Sch Med, Dept Microbiol, Ube, Yamaguchi 7558505, Japan

[12] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[13] Louisiana State Univ, Med Ctr, New Orleans, LA 70112 USA

[14] Univ Puerto Rico, Dept Biol, Rio Piedras, PR 00931 USA

[15] NYU, Sch Med, Dept Med, New York, NY 10016 USA

[16] Karolinska Inst, MTC, SE-17177 Stockholm, Sweden

[17] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

[18] Umea Univ, Dept Med Biochem & Biophys, SE-90187 Umea, Sweden

来源：

SCIENCE | 2004年 / 305卷 / 5683期

关键词：

D O I：

10.1126/science.1098801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens ( generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best ( specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O - dominant human populations.

引用

页码：519 / 522

页数：4

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