Proteins involved in the synaptic organization of AMPA (α-amino-3-hydroxy-5-methylisoxazolepropionate) receptors

被引:4
作者
Henley, J [1 ]
机构
[1] Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
关键词
GluR subunits; NSF; PDZ domains; PICK1; protein kinase C;
D O I
10.1042/BST0290485
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As well mediating most synaptic transmission in the mammalian central nervous system, alpha -amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors are involved in the processes of synapse formation, stabilization and plasticity. Thus the mechanisms that control the developmental and activity-dependent changes in the functional synaptic expression of AMPA receptors are of fundamental importance. In the last few years dramatic advances have been achieved towards elucidating some of the molecular events involved, and a previously unsuspected complexity of proteins that selectively interact directly indirectly with individual AMA receptor subunits have been identified. Here I present an overview of some of the main interacting proteins, and describe what we know about how these may fit into cellular pathways that control AMPA receptor targeting, trafficking and functional expression.
引用
收藏
页码:485 / 488
页数:4
相关论文
共 32 条
[31]   Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins [J].
Xia, J ;
Chung, HJ ;
Wihler, C ;
Huganir, RL ;
Linden, DJ .
NEURON, 2000, 28 (02) :499-510
[32]   Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1 [J].
Xia, J ;
Zhang, XQ ;
Staudinger, J ;
Huganir, RL .
NEURON, 1999, 22 (01) :179-187