共 32 条
Proteins involved in the synaptic organization of AMPA (α-amino-3-hydroxy-5-methylisoxazolepropionate) receptors
被引:4
作者:
Henley, J
[1
]
机构:
[1] Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
关键词:
GluR subunits;
NSF;
PDZ domains;
PICK1;
protein kinase C;
D O I:
10.1042/BST0290485
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
As well mediating most synaptic transmission in the mammalian central nervous system, alpha -amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors are involved in the processes of synapse formation, stabilization and plasticity. Thus the mechanisms that control the developmental and activity-dependent changes in the functional synaptic expression of AMPA receptors are of fundamental importance. In the last few years dramatic advances have been achieved towards elucidating some of the molecular events involved, and a previously unsuspected complexity of proteins that selectively interact directly indirectly with individual AMA receptor subunits have been identified. Here I present an overview of some of the main interacting proteins, and describe what we know about how these may fit into cellular pathways that control AMPA receptor targeting, trafficking and functional expression.
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页码:485 / 488
页数:4
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