Gearing up for genome-wide gene-association studies

被引：26

作者：

Farrall, M ^{[1
]}

Morris, AP ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Dept Cardiovasc Med, Oxford OX3 7BN, England

来源：

HUMAN MOLECULAR GENETICS | 2005年 / 14卷

基金：

英国惠康基金;

关键词：

D O I：

10.1093/hmg/ddi273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the grand challenges of human genetics to systematically map by gene-association susceptibility genes for complex diseases is underway. High-throughput genotyping platforms have been developed; a comprehensive map of human genetic variation (HapMap) to guide efficient marker selection is imminent and many researchers have assembled suitable cohorts of patients. Expectations are understandably high and it is timely to review the promise and pitfalls of this strategy.

引用

页码：R157 / R162

页数：6

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