Liver regeneration

被引：1171

作者：

Michalopoulos, George K. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 213卷 / 02期

关键词：

D O I：

10.1002/jcp.21172

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.

引用

页码：286 / 300

页数：15

共 222 条

[1] GROWTH FACTOR-REGULATED PATHWAYS IN EPITHELIAL-CELL PROLIFERATION [J].

AARONSON, SA ;

RUBIN, JS ;

FINCH, PW ;

WONG, J ;

MARCHESE, C ;

FALCO, J ;

TAYLOR, WG ;

KRAUS, MH .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (06) :S7-S10

[2] ANTIBODIES TO TUMOR-NECROSIS-FACTOR-ALPHA INHIBIT LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY [J].

AKERMAN, P ;

COTE, P ;

YANG, SQ ;

MCCLAIN, C ;

NELSON, S ;

BAGBY, GJ ;

DIEHL, AM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (04) :G579-G585

[3] Update on hepatic stem cells [J].

Alison, MR ;

Poulsom, R ;

Forbes, SJ .

LIVER, 2001, 21 (06) :367-373

[4]

APPASAMY R, 1993, LAB INVEST, V68, P270

[5] Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication [J].

Argast, GM ;

Campbell, JS ;

Brooling, JT ;

Fausto, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) :34530-34536

[6] Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation [J].

Asai, Keiko ;

Tamakawa, Susumu ;

Yamamoto, Masahiro ;

Yoshie, Masumi ;

Tokusashi, Yoshihiko ;

Yaginuma, Yuji ;

Kasai, Shinichi ;

Ogawa, Katsuhiro .

LIVER INTERNATIONAL, 2006, 26 (05) :595-603

[7] An overview of the Notch signalling pathway [J].

Baron, M .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (02) :113-119

[8] Multiple levels of Notch signal regulation (Review) [J].

Baron, M ;

Aslam, H ;

Flasza, M ;

Fostier, M ;

Higgs, JE ;

Mazaleyrat, SL ;

Wilkin, MB .

MOLECULAR MEMBRANE BIOLOGY, 2002, 19 (01) :27-38

[9] Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver [J].

Battle, Michele A. ;

Konopka, Genevieve ;

Parviz, Fereshteh ;

Gaggl, Alexandra Lerch ;

Yang, Chuhu ;

Sladek, Frances M. ;

Duncan, Stephen A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (22) :8419-8424

[10] Phenobarbital regulates nuclear expression of HNF-4α in mouse and rat Hepatocytes independent of CAR and PXR [J].

Bell, Aaron W. ;

Michalopoulos, George K. .

HEPATOLOGY, 2006, 44 (01) :186-194

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