Liver regeneration

被引：1171

作者：

Michalopoulos, George K. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 213卷 / 02期

关键词：

D O I：

10.1002/jcp.21172

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.

引用

页码：286 / 300

页数：15

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