Vaccines and the Future of Human Immunology

被引：68

作者：

Germain, Ronald N. ^{[1
,2
,3
]}

机构：

[1] NIAID, Lymphocyte Biol Sect, NIH, Bethesda, MD 20892 USA

[2] NIAID, Program Syst Immunol & Infect Dis Modeling, Immunol Lab, NIH, Bethesda, MD 20892 USA

[3] NIH, Trans NIH Ctr Human Immunol Autoimmun & Inflammat, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2010年 / 33卷 / 04期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; SPECTROMETRY-BASED PROTEOMICS; CYTOPLASMIC FREE CALCIUM; YELLOW-FEVER VACCINE; MEMORY B-CELLS; T-CELLS; MASS-SPECTROMETRY; PRIMARY IMMUNODEFICIENCIES; INFECTIOUS-DISEASES; MOLECULAR-CLONING;

D O I：

10.1016/j.immuni.2010.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, a collection of detailed reviews summarizes needs, opportunities, and roadblocks to the development of new vaccines, all in the context of our current knowledge and understanding of key aspects of immune function and microbial interactions with the host This Perspective is designed to provide a broad overview that discusses our present limitations in designing effective novel vaccines for diseases that do not typically induce robust resistance in infected individuals and how the addition of a systems-level, multiplexed approach to the analysis of the human immune system can complement traditional highly focused research efforts to accelerate our progress toward this goal and the improvement of human health

引用

页码：441 / 450

页数：10

共 89 条

[81] Development of therapeutic HPV vaccines [J].

Trimble, Cornelia L. ;

Frazer, Ion H. .

LANCET ONCOLOGY, 2009, 10 (10) :975-980

[82] The sequence of the human genome [J].

Venter, JC ;

Adams, MD ;

Myers, EW ;

Li, PW ;

Mural, RJ ;

Sutton, GG ;

Smith, HO ;

Yandell, M ;

Evans, CA ;

Holt, RA ;

Gocayne, JD ;

Amanatides, P ;

Ballew, RM ;

Huson, DH ;

Wortman, JR ;

Zhang, Q ;

Kodira, CD ;

Zheng, XQH ;

Chen, L ;

Skupski, M ;

Subramanian, G ;

Thomas, PD ;

Zhang, JH ;

Miklos, GLG ;

Nelson, C ;

Broder, S ;

Clark, AG ;

Nadeau, C ;

McKusick, VA ;

Zinder, N ;

Levine, AJ ;

Roberts, RJ ;

Simon, M ;

Slayman, C ;

Hunkapiller, M ;

Bolanos, R ;

Delcher, A ;

Dew, I ;

Fasulo, D ;

Flanigan, M ;

Florea, L ;

Halpern, A ;

Hannenhalli, S ;

Kravitz, S ;

Levy, S ;

Mobarry, C ;

Reinert, K ;

Remington, K ;

Abu-Threideh, J ;

Beasley, E .

SCIENCE, 2001, 291 (5507) :1304-+

[83] B-cell self-tolerance in humans [J].

Wardemann, Hedda ;

Nussenzweig, Michel C. .

ADVANCES IN IMMUNOLOGY, VOL 95, 2007, 95 :83-110

[84] Progress towards a dengue vaccine [J].

Webster, Daniel P. ;

Farrar, Jeremy ;

Rowland-Jones, Sarah .

LANCET INFECTIOUS DISEASES, 2009, 9 (11) :678-687

[85] ROLE OF T3 SURFACE MOLECULES IN HUMAN T-CELL ACTIVATION - T3-DEPENDENT ACTIVATION RESULTS IN AN INCREASE IN CYTOPLASMIC FREE CALCIUM [J].

WEISS, A ;

IMBODEN, J ;

SHOBACK, D ;

STOBO, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :4169-4173

[86]

Weiss A, 1991, Semin Immunol, V3, P313

[87] RESTRICTION OF IN-VITRO T CELL-MEDIATED CYTOTOXICITY IN LYMPHOCYTIC CHORIOMENINGITIS WITHIN A SYNGENEIC OR SEMIALLOGENEIC SYSTEM [J].

ZINKERNA.RM ;

DOHERTY, PC .

NATURE, 1974, 248 (5450) :701-702

[88] THYMUS AND LYMPHOHEMOPOIETIC CELLS - THEIR ROLE IN T CELL MATURATION IN SELECTION OF T-CELLS H-2-RESTRICTION-SPECIFICITY AND IN H-2 LINKED IR GENE CONTROL [J].

ZINKERNAGEL, RM .

IMMUNOLOGICAL REVIEWS, 1978, 42 :224-270

[89] Papillomaviruses in the causation of human cancers - a brief historical account [J].

zur Hausen, Harald .

VIROLOGY, 2009, 384 (02) :260-265

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