Simple and rapid detection method using surface plasmon resonance for dioxins, polychlorinated biphenylx and atrazine

被引：76

作者：

Shimomura, M ^{[1
]}

Nomura, Y ^{[1
]}

Zhang, W ^{[1
]}

Sakino, M ^{[1
]}

Lee, KH ^{[1
]}

Ikebukuro, K ^{[1
]}

Karube, I ^{[1
]}

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan

来源：

ANALYTICA CHIMICA ACTA | 2001年 / 434卷 / 02期

关键词：

endocrine disrupting chemicals; TCDD; PCB; atrazine; SPR; immunoassay;

D O I：

10.1016/S0003-2670(01)00809-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Endocrine disrupting chemicals (EDCs) such as dioxins, PCBs and pesticides are very harmful to human. In this work, a rapid detection method for 2,3,7,8-TCDD, PCB, and atrazine is described, which is based upon a competitive immunoassay using surface plasmon resonance (SPR). With this method, it was possible to detect 2,3,7,8-TCDD, PCB, and atrazine with respective detection limits of 0.1, 2.5, and 5 ng ml(-1), requiring 15 min for a single sample measurement. To achieve better sensitivities, a sandwich assay was additionally performed. For dioxins and atrazine, response amplification could be observed, enabling better differentiation of small concentration differences among analytes. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 230

页数：8

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