Oleanane-type Triterpene Glucuronides from the Roots of Glycyrrhiza uralensis Fischer

被引：42

作者：

Zheng, Yun-Feng ^{[1
,2
]}

Qi, Lian-Wen ^{[1
]}

Cui, Xiao-Bing ^{[2
]}

Peng, Guo-Ping ^{[2
]}

Peng, Yong-Bo ^{[1
]}

Ren, Mei-Ting ^{[1
]}

Cheng, Xiao-Lan ^{[1
]}

Li, Ping ^{[1
]}

机构：

[1] China Pharmaceut Univ, Key Lab Modern Chinese Med, Minist Educ, Nanjing 210009, Peoples R China

[2] Nanjing Univ Chinese Med, Sch Pharm, Nanjing, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 13期

关键词：

Glycyrrhiza uralensis Fischer; Glycyrrhiza; Leguminosae; triterpene glucuronides; uralsaponins C-F; cytotoxic activities; NORTHEASTERN CHINA; CONSTITUENTS; SAPOGENOL; SAPONIN;

D O I：

10.1055/s-0029-1240907

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Investigation of characteristic constituents of the roots of Glycyrrhiza uralensis Fischer led to isolation of four new triterpene glucuronides, namely uralsaponins C-F (1-4), an artificial product, namely the methyl ester of glycyrrhizin (5), as well as six known triterpene glucuronides (611). These new compounds were identified by 1D and 2D NMR spectroscopic analysis. The cytotoxicity of the selected compounds and their aglycones were evaluated against HeLa and MCF-7 cancer cell lines, and the preliminary structure-activity relationship was also elucidated.

引用

页码：1457 / 1463

页数：7

共 14 条

[1]

Triterpene Glycosides from Antarctic Sea Cucumbers. 2. Structure of Achlioniceosides A1, A2, and A3 from the Sea Cucumber Achlionice violaecuspidata (=Rhipidothuria racowitzai) [J].