Theory of force regulation by Nascent adhesion sites

被引：68

作者：

Bruinsma, R ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90024 USA

来源：

BIOPHYSICAL JOURNAL | 2005年 / 89卷 / 01期

关键词：

D O I：

10.1529/biophysj.104.048280

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The mechanical coupling of a cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces generated along the F-Actin. laments of the cytoskeleton to connecting tissue. Nascent adhesion sites have been shown to regulate these forces in response to tissue rigidity. Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stationary adhesion sites, according to elasticity theory. A simple model is presented to describe force regulation by dynamical adhesion sites.

引用

页码：87 / 94

页数：8

共 24 条

[11] Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin [J].

Jiang, GY ;

Giannone, G ;

Critchley, DR ;

Fukumoto, E ;

Sheetz, MP .

NATURE, 2003, 424 (6946) :334-337

[12]

Landau L D, 1988, THEORY ELASTICITY

[13] Cell migration: A physically integrated molecular process [J].

Lauffenburger, DA ;

Horwitz, AF .

CELL, 1996, 84 (03) :359-369

[14] Cell movement is guided by the rigidity of the substrate [J].

Lo, CM ;

Wang, HB ;

Dembo, M ;

Wang, YL .

BIOPHYSICAL JOURNAL, 2000, 79 (01) :144-152

[15] Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy [J].

Merkel, R ;

Nassoy, P ;

Leung, A ;

Ritchie, K ;

Evans, E .

NATURE, 1999, 397 (6714) :50-53

[16] Talin: an emerging focal point of adhesion dynamics [J].

Nayal, A ;

Webb, DJ ;

Horwitz, AF .

CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (01) :94-98

[17] TRACTION FORCES IN LOCOMOTING CELLS [J].

OLIVER, T ;

DEMBO, M ;

JACOBSON, K .

CELL MOTILITY AND THE CYTOSKELETON, 1995, 31 (03) :225-240

[18] Cell locomotion and focal adhesions are regulated by substrate flexibility [J].

Pelham, RJ ;

Wang, YL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13661-13665

[19] Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism [J].

Riveline, D ;

Zamir, E ;

Balaban, NQ ;

Schwarz, US ;

Ishizaki, T ;

Narumiya, S ;

Kam, Z ;

Geiger, B ;

Bershadsky, AD .

JOURNAL OF CELL BIOLOGY, 2001, 153 (06) :1175-1185

[20] Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins [J].

Schmidt, C ;

Pommerenke, H ;

Dürr, F ;

Nebe, B ;

Rychly, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (09) :5081-5085

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