Enantioselective dioxygenase-catalysed formation and thermal racemisation of chiral thiophene sulfoxides

被引：27

作者：

Boyd, DR ^{[1
]}

Sharma, ND ^{[1
]}

Haughey, SA ^{[1
]}

Malone, JF ^{[1
]}

McMurray, BT ^{[1
]}

Sheldrake, GN ^{[1
]}

Allen, CCR ^{[1
]}

Dalton, H ^{[1
]}

机构：

[1] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 20期

关键词：

D O I：

10.1039/cc9960002363

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Substituted chiral thiophene 1-oxides and their cycloadducts of variable enantiopurity have been isolated as products of dioxygenase-catalysed sulfoxidation of the corresponding thiophenes using intact cells of Pseudomonas putida; thermal racemization (Delta G(double dagger) = 25.1 kcal mol(-1)) of the enantiopure metabolite (1R)-2-methylbenzo[b]thiophene 1-oxide has been observed.

引用

页码：2363 / 2364

页数：2

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