Asymmetric synthesis of (2R,5R)-2,5-diaminohexan-1,6-dioic acid

被引：16

作者：

Bull, SD

Chernega, AN

Davies, SG

Moss, WO

Parkin, RM

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Oxford, Chem Crystallog Lab, Oxford OX1 3PD, England

[3] Zeneca Pharmaceut, Macclesfield SK10 2NA, Cheshire, England

来源：

TETRAHEDRON | 1998年 / 54卷 / 35期

关键词：

D O I：

10.1016/S0040-4020(98)00492-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Schollkopf's auxiliary 16 was added to bis-lactim iodide 21 to give 1,2-bis[(3S,6R)-3,6- dihydro-2,5-dimethoxy-3-isopropylpyrazin-6-yl]ethane 22 in 50% d.e. Dimer 22 was separated from its diastereoisomer 23 and deprotected using 6M HCl to afford homochiral (2R,5R)-2,5-diaminohexan-1,6-dioic acid 24. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：10379 / 10388

页数：10

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