Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain

被引:78
作者
Berg, Daniel A. [1 ]
Kirkham, Matthew [1 ]
Beljajeva, Anna [1 ]
Knapp, Dunja [2 ]
Habermann, Bianca [3 ]
Ryge, Jesper [4 ]
Tanaka, Elly M. [2 ]
Simon, Andras [1 ]
机构
[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
[2] Ctr Regenerat Therapies, D-01307 Dresden, Germany
[3] Max Planck Inst, D-01307 Dresden, Germany
[4] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
来源
DEVELOPMENT | 2010年 / 137卷 / 24期
基金
瑞典研究理事会;
关键词
6-OHDA; Adult neurogenesis; Dopamine; Midbrain; Neuronal stem cell; Salamander; MAMMALIAN SUBSTANTIA-NIGRA; AXOLOTL TAIL REGENERATION; SPINAL-CORD REGENERATION; RADIAL GLIAL-CELLS; NEURAL STEM-CELLS; LENS REGENERATION; ZEBRAFISH; PROLIFERATION; MIGRATION; NEURONS;
D O I
10.1242/dev.055541
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In contrast to mammals, salamanders and teleost fishes can efficiently repair the adult brain. It has been hypothesised that constitutively active neurogenic niches are a prerequisite for extensive neuronal regeneration capacity. Here, we show that the highly regenerative salamander, the red spotted newt, displays an unexpectedly similar distribution of active germinal niches with mammals under normal physiological conditions. Proliferation zones in the adult newt brain are restricted to the forebrain, whereas all other regions are essentially quiescent. However, ablation of midbrain dopamine neurons in newts induced ependymoglia cells in the normally quiescent midbrain to proliferate and to undertake full dopamine neuron regeneration. Using oligonucleotide microarrays, we have catalogued a set of differentially expressed genes in these activated ependymoglia cells. This strategy identified hedgehog signalling as a key component of adult dopamine neuron regeneration. These data show that brain regeneration can occur by activation of neurogenesis in quiescent brain regions.
引用
收藏
页码:4127 / 4134
页数:8
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