Signaling by dual specificity kinases

被引：277

作者：

Dhanasekaran, N ^{[1
]}

Reddy, EP

机构：

[1] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19104 USA

[2] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19104 USA

来源：

ONCOGENE | 1998年 / 17卷 / 11期

关键词：

oncogene; apoptosis; cell transformation; MAP kinase; MEKK; MEK; MKK; ERK; JNK; signal transduction;

D O I：

10.1038/sj.onc.1202251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven distinct mammalian MAP kinases kinases have been identified. Same of the unique signaling properties of these kinases are discussed here.

引用

页码：1447 / 1455

页数：9

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