Activity of human β-defensin 3 alone or combined with other antimicrobial agents against oral bacteria

被引：78

作者：

Maisetta, G

Batoni, G

Esin, S

Luperini, F

Pardini, M

Bottai, D

Florio, W

Giuca, MR

Gabriele, M

Campa, M

机构：

[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy

[2] Univ Pisa, Dipartimento Neurosci, I-56127 Pisa, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 10期

关键词：

D O I：

10.1128/AAC.47.10.3349-3351.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.

引用

页码：3349 / 3351

页数：3

共 10 条

[1]

BATONI G, 1993, EUR J EPIDEMIOL, V9, P483

[2] The novel human beta-defensin-3 is widely expressed in oral tissues [J].