Delivery of epitopes by the Salmonella type III secretion system for vaccine development

被引：229

作者：

Rüssmann, H

Shams, H

Poblete, F

Fu, YX

Galán, JE ^{[1
]}

Donis, RO

机构：

[1] SUNY Stony Brook, Sch Med, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] Univ Nebraska, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

来源：

SCIENCE | 1998年 / 281卷 / 5376期

关键词：

D O I：

10.1126/science.281.5376.565

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class I-restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection.

引用

页码：565 / 568

页数：4

共 35 条

[1] HAM-2 CORRECTS THE CLASS-I ANTIGEN-PROCESSING DEFECT IN RMA-S CELLS [J].