Chemerin - A new adipokine that modulates adipogenesis via its own receptor

被引:362
作者
Roh, Sang-Gun [1 ]
Song, Sang-Houn
Choi, Ki-Choon
Katoh, Kazuo
Wittamer, Valerie
Parmentier, Marc
Sasaki, Shin-ichi
机构
[1] Shinshu Univ, Fac Agr, Dept Food Prod Sci, Nagano 3994598, Japan
[2] Tohoku Univ, Grad Sch Agr Sci, Dept Anim Physiol, Sendai, Miyagi 9818555, Japan
[3] Univ Libre Bruxelles, Inst Rech Interdisciplinaire Biol Humaine & Mol, B-1070 Brussels, Belgium
关键词
chemerin; chemerin receptor; adipogenesis; adipokine;
D O I
10.1016/j.bbrc.2007.08.104
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chemerin, an 18 kDa protein secreted by adipose tissue, was reported to modulate immune system function through its binding to the chemerin receptor (chemerinR). We herein demonstrate that chemerin also influences adipose cell function. Our data showed that chemerin and chemerinR mRNA expressions were highly expressed in adipose tissues, and that their expression levels were up-regulated in mice fed a high-fat diet. Both chemerin and chemerinR mRNA expression dramatically increased during the differentiation of 3T3-L1 cells and human preadipocytes into adipocytes. Furthermore, recombinant chemerin induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK 1/2) and lipolysis in differentiated 3T3-L1 adipocytes. Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:1013 / 1018
页数:6
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