To cre or not to cre - The next generation of mouse models of human cardiac diseases

被引:26
作者
Chien, KR [1 ]
机构
[1] Univ Calif San Diego, Sch Med, Inst Mol Med, La Jolla, CA 92093 USA
关键词
transgenic mouse models; heart disease; cardiomyopathy; gene targeting; homologous recombination;
D O I
10.1161/01.RES.88.6.546
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:546 / 549
页数:4
相关论文
共 44 条
[41]  
SUBRAMANIAM A, 1991, J BIOL CHEM, V266, P24613
[42]   RXR-ALPHA MUTANT MICE ESTABLISH A GENETIC-BASIS FOR VITAMIN-A SIGNALING IN HEART MORPHOGENESIS [J].
SUCOV, HM ;
DYSON, E ;
GUMERINGER, CL ;
PRICE, J ;
CHIEN, KR ;
EVANS, RM .
GENES & DEVELOPMENT, 1994, 8 (09) :1007-1018
[43]   FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium [J].
Tevosian, SG ;
Deconinck, AE ;
Tanaka, M ;
Schinke, M ;
Litovsky, SH ;
Izumo, S ;
Fujiwara, Y ;
Orkin, SH .
CELL, 2000, 101 (07) :729-739
[44]   Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression [J].
Wang, JM ;
Wilhelmsson, H ;
Graff, C ;
Li, H ;
Oldfors, A ;
Rustin, P ;
Brüning, JC ;
Kahn, CR ;
Clayton, DA ;
Barsh, GS ;
Thorén, P ;
Larsson, NG .
NATURE GENETICS, 1999, 21 (01) :133-137