Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation

被引:79
作者
Tetzlaff, MT [1 ]
Jackle, H [1 ]
Pankratz, MJ [1 ]
机构
[1] MAX PLANCK INST BIOPHYS CHEM,ABT MOL ENTWICKLUNGSBIOL,D-37018 GOTTINGEN,GERMANY
关键词
actin cytoskeleton; germ cell formation; head morphogenesis; oskar mRNA localization; tropomyosin;
D O I
10.1002/j.1460-2075.1996.tb00466.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Drosophila encodes five muscle and one cytoskeletal isoform of the actin-binding protein tropomyosin, We have identified a lack-of-function mutation in the cytoskeletal isoform (cTmII), Zygotic mutant embryos show a defect in head morphogenesis, while embryos lacking maternal cTmII are defective in germ cell formation but otherwise give rise to viable adults, oskar mRNA, which is required for both germ cell formation and abdominal segmentation, fails to accumulate at the posterior pole in these embryos, nanos mRNA, however, which is required exclusively for abdominal segmentation, is localized at wild-type levels, These results indicate that head morphogenesis and the accumulation of high levels of oskar mRNA necessary for germ cell formation require tropomyosin-dependent cytoskeleton.
引用
收藏
页码:1247 / 1254
页数:8
相关论文
共 56 条
[1]   A NEW TROPOMYOSIN ESSENTIAL FOR CYTOKINESIS IN THE FISSION YEAST S-POMBE [J].
BALASUBRAMANIAN, MK ;
HELFMAN, DM ;
HEMMINGSEN, SM .
NATURE, 1992, 360 (6399) :84-87
[2]  
BRAY D, 1992, CELL MOVENTS
[3]  
Campos-Ortega J. A., 1997, The Embryonic Development of Drosophila melanogaster, Vsecond
[4]  
CHOU TB, 1993, DEVELOPMENT, V119, P1359
[5]   TRANSIENT POSTERIOR LOCALIZATION OF A KINESIN FUSION PROTEIN REFLECTS ANTEROPOSTERIOR POLARITY OF THE DROSOPHILA OOCYTE [J].
CLARK, I ;
GINIGER, E ;
RUOHOLABAKER, H ;
JAN, LY ;
JAN, YN .
CURRENT BIOLOGY, 1994, 4 (04) :289-300
[6]   CHICKADEE ENCODES A PROFILIN REQUIRED FOR INTERCELLULAR CYTOPLASM TRANSPORT DURING DROSOPHILA OOGENESIS [J].
COOLEY, L ;
VERHEYEN, E ;
AYERS, K .
CELL, 1992, 69 (01) :173-184
[7]   OSKAR ORGANIZES THE GERM PLASM AND DIRECTS LOCALIZATION OF THE POSTERIOR DETERMINANT NANOS [J].
EPHRUSSI, A ;
DICKINSON, LK ;
LEHMANN, R .
CELL, 1991, 66 (01) :37-50
[8]   INDUCTION OF GERM-CELL FORMATION BY OSKAR [J].
EPHRUSSI, A ;
LEHMANN, R .
NATURE, 1992, 358 (6385) :387-392
[9]   STAUFEN PROTEIN ASSOCIATES WITH THE 3'UTR OF BICOID MESSENGER-RNA TO FORM PARTICLES THAT MOVE IN A MICROTUBULE-DEPENDENT MANNER [J].
FERRANDON, D ;
ELPHICK, L ;
NUSSLEINVOLHARD, C ;
STJOHNSTON, D .
CELL, 1994, 79 (07) :1221-1232
[10]   POLARIZATION OF BOTH MAJOR BODY AXES IN DROSOPHILA BY GURKEN-TORPEDO SIGNALING [J].
GONZALEZREYES, A ;
ELLIOTT, H ;
STJOHNSTON, D .
NATURE, 1995, 375 (6533) :654-658