A general method for the synthesis of N-protected alpha-aminoalkylphosphinic acids

被引：26

作者：

Chen, SJ

Coward, JK

机构：

[1] UNIV MICHIGAN, COLL PHARM, INTERDEPARTMENTAL PROGRAM MED CHEM, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, DEPT CHEM, ANN ARBOR, MI 48109 USA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期

关键词：

D O I：

10.1016/0040-4039(96)00839-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and highly convenient method for the synthesis of N-protected alpha-aminophosphinic acids, suitable for side chain elongation either from N-, P-, or C- termini to form a variety of phosphinic peptides, has been developed. The desired phosphinic acids were obtained in moderate to satisfactory yield by a three-component condensation reaction of benzyl carbamate, an aldehyde, and an alkylphosphonous acid (or its 1-adamantanamine salt) in acetyl chloride under very mild conditions. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：4335 / 4338

页数：4

共 39 条

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