Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities

被引：11

作者：

Morihira, K

Nishimori, T

Kusama, H

Horiguchi, Y

Kuwajima, I

Tsuruo, T

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

antineoplastics; antitumor compounds; terpenes and terpenoids;

D O I：

10.1016/S0960-894X(98)00540-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2977 / 2982

页数：6

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