TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells

被引：32

作者：

Inoue, M ^{[1
]}

Zhai, HF

Sakazaki, H

Furuyama, H

Fukuyama, Y

Hirama, M

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Inst Pharmacol, Tokushima 7708514, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期

关键词：

peptides; proteasome inhibitor; neuritogenesis; TMC-95A; PC12; cells;

D O I：

10.1016/j.bmcl.2003.11.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 muM. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：663 / 665

页数：3

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