Baker's yeast reduction of PEG-linked acetoacetate

被引：6

作者：

Bonora, GM ^{[1
]}

Drioli, S ^{[1
]}

Forzato, C ^{[1
]}

Nitti, P ^{[1
]}

Pitacco, G ^{[1
]}

机构：

[1] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy

来源：

LETTERS IN ORGANIC CHEMISTRY | 2005年 / 2卷 / 01期

关键词：

Baker's yeast; bioreduction; organic solvent; PEG;

D O I：

10.2174/1570178053400135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioreduction of PEG-acetoacetate 1 is achieved using dry baker's yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)-3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.

引用

页码：89 / 91

页数：3

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