Chemoenzymatic polymer-supported liquid phase synthesis of glucose γ-aminobutyric ester

被引：5

作者：

de Torres, C ^{[1
]}

Fernández-Mayoralas, A ^{[1
]}

机构：

[1] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 11期

关键词：

glucose gamma-aminobutyric acid ester; polymer-supported solution synthesis; lipase; regioselective acylation;

D O I：

10.1016/S0040-4039(03)00223-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, polymer-supported solution synthesis of 6-O-(gamma-aminobutyryl)-D-glucose has been achieved. Glucose was attached to polyethylene glycol monomethyl ether (MPEG) through an alpha,alpha'-dioxyxylyl diether linker, and, subsequently, the HO-6 hydroxyl of the glucose was regioselectively esterified with gamma-aminobutyric acid by a lipase-catalyzed reaction. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2383 / 2385

页数：3

共 13 条

[1]

[Anonymous], 1986, NEUROCHEMISTRY FUNDA

[2]

AUDUS KL, 1992, ADV DRUG RES, V23, P1

[3] POLYMER-SUPPORTED SOLUTION SYNTHESIS OF OLIGOSACCHARIDES USING A NOVEL VERSATILE LINKER FOR THE SYNTHESIS OF D-MANNOPENTAOSE, A STRUCTURAL UNIT OF D-MANNANS OF PATHOGENIC YEASTS [J].