Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds

被引:58
作者
Fleer, H.
Verspohl, E. J.
机构
[1] Univ Munster, Inst Pharmazeut & Med Chem, Abt Pharmakol, D-48149 Munster, Germany
[2] Univ Munster, Inst Pharmazeut Biol & Phytochem, D-48149 Munster, Germany
关键词
Plantago lanceolata; antispasmodic effect; ileum; trachea;
D O I
10.1016/j.phymed.2006.05.006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ali ethanolic spissum extract of the aerial parts of Plantago lanceolata L. was examined for antispasmodic activity on isolated ileum and trachea of the guinea-pig. Isolated constituents were investigated as well. The P. lanceolata extract inhibited the contractions of the guinea-pig ileum that were induced by various agonists such as acetylcholine (ACh), histamine. potassium and barium ions. Additionally the trachea contractions induced by barium ions were inhibited. The compounds luteolin, acteoside, plantamajoside an catalpol peracetate but not catalpol, isoacteoside, lavandulifolioside and aucubin inhibited the ACh-induced contractions of the guinea-pig ileum. Luteolin and acteoside reduced the barium-induced contractions of the guinea-pig trachea. Two recently isolated compounds did not show antispasmodic activity: luteolin-3',7-diglucuronide and beta-hydroxy-acteoside. (C) 2006 Elsevier GmbH. All rights reserved.
引用
收藏
页码:409 / 415
页数:7
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