Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives

被引：42

作者：

Ha, SK

Koketsu, M

Lee, K

Choi, SY

Park, JH

Ishihara, H

Kim, SY ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch E W Med Sci, Suwon 449701, South Korea

[2] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan

[3] Korea Food Res Inst, Songnam 463746, South Korea

[4] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 05期

关键词：

N; N-unsubstituted selenourea; tyrosinase inhibitor;

D O I：

10.1248/bpb.28.838

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigated inhibitory effects of N,N-unsubstituted selenourea derivatives on tyrosinase activity. Three types of N,N-unsubstituted selenoureas derivatives exhibited inhibitory effect on dopa (3,4-dihydroxyphenylalanine) oxidase activity of mushroom tyrosinase. Compound D at a concentration of 200 mu M exhibited 55.5% of inhibition on dopa oxidase activity of mushroom tyrosinase. This inhibitory effect was higher than that of kojic acid (39.4%), a well known tyrosinase inhibitor. Moreover, the compound D identified as a noncompetitive inhibitor by Lineweaver-Burk plot analysis. In addition, compound D also inhibited the melanin production in melan-a cells.

引用

页码：838 / 840

页数：3

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