Small-molecule delivery by nanoparticles for anticancer therapy

被引：172

作者：

Chen, Zhuo ^{[1
,2
]}

机构：

[1] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[2] Winship Canc Inst, Atlanta, GA USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2010年 / 16卷 / 12期

关键词：

PEGYLATED LIPOSOMAL DOXORUBICIN; POLYMER CONJUGATE IT-101; ALBUMIN-BOUND PACLITAXEL; IN-VIVO; DRUG-DELIVERY; PHASE-I; BIOMEDICAL APPLICATIONS; TARGETED NANOPARTICLES; POLY(L-GLUTAMIC ACID); ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.molmed.2010.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity. Current research in this field focuses on understanding precisely how small molecules are released from nanoparticles and delivered to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field.

引用

页码：594 / 602

页数：9

共 102 条

[1]

Nanoparticle-induced vascular blockade in human prostate cancer [J].

Agemy, Lilach ;

Sugahara, Kazuki N. ;

Kotamraju, Venkata Ramana ;

Gujraty, Kunal ;

Girard, Olivier M. ;

Kono, Yuko ;

Mattrey, Robert F. ;

Park, Ji-Ho ;

Sailor, Michael J. ;

Jimenez, Ana I. ;

Cativiela, Carlos ;

Zanuy, David ;

Sayago, Francisco J. ;

Aleman, Carlos ;

Nussinov, Ruth ;

Ruoslahti, Erkki .

BLOOD, 2010, 116 (15) :2847-2856

[2]

HER-2-Targeted Nanoparticle-Affibody Bioconjugates for Cancer Therapy [J].

Alexis, Frank ;

Basto, Pamela ;

Levy-Nissenbaum, Etgar ;

Radovic-Moreno, Aleksandar F. ;

Zhang, Liangfang ;

Pridgen, Eric ;

Wang, Andrew Z. ;

Marein, Shawn L. ;

Westerhof, Katrina ;

Molnar, Linda K. ;

Farokhzad, Omid C. .

CHEMMEDCHEM, 2008, 3 (12) :1839-1843

[3]

LONG-CIRCULATING (STERICALLY STABILIZED) LIPOSOMES FOR TARGETED DRUG-DELIVERY [J].

ALLEN, TM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :215-220

[4]

Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy [J].

Bae, Y ;

Nishiyama, N ;

Fukushima, S ;

Koyama, H ;

Yasuhiro, M ;

Kataoka, K .

BIOCONJUGATE CHEMISTRY, 2005, 16 (01) :122-130

[5]

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [J].

Bartlett, Derek W. ;

Su, Helen ;

Hildebrandt, Isabel J. ;

Weber, Wolfgang A. ;

Davis, Mark E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15549-15554

[6]

Bharali DJ, 2009, INT J NANOMED, V4, P1

[7]

Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin [J].

Bhatt, RL ;

de Vries, P ;

Tulinsky, J ;

Bellamy, G ;

Baker, B ;

Singer, JW ;

Klein, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :190-193

[8]

uPAR: A versatile signalling orchestrator [J].

Blasi, F ;

Carmeliet, P .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (12) :932-943

[9]

A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules [J].

Boddy, AV ;

Plummer, ER ;

Todd, R ;

Sludden, J ;

Griffin, M ;

Robson, L ;

Cassidy, J ;

Bissett, D ;

Bernareggi, A ;

Verrill, MW ;

Calvert, AH .

CLINICAL CANCER RESEARCH, 2005, 11 (21) :7834-7840

[10]

Preparation and characterization of a magnetic and optical dual-modality molecular probe [J].

Bumb, A. ;

Regino, C. A. S. ;

Perkins, M. R. ;

Bernardo, M. ;

Ogawa, M. ;

Fugger, L. ;

Choyke, P. L. ;

Dobson, P. J. ;

Brechbiel, M. W. .

NANOTECHNOLOGY, 2010, 21 (17)

← 1 2 3 4 5 6 7 8 9 10 →