The angiotensin I converting enzyme gene as a susceptibility factor for dementia

被引：36

作者：

Richard, F

Fromentin-David, I

Ricolfi, F

Ducimetière, P

Di Menza, C

Amouyel, P

Helbecque, N

机构：

[1] Inst Pasteur, INSERM U508, F-59019 Lille, France

[2] Assistance Publ Hop Paris, Ctr Hosp Emile Roux, Serv Gerontol Clin, Limeil Brevannes, France

[3] Assistance Publ Hop Paris, Creteil, France

[4] Ctr Hosp Henri Mondor, Serv Neuroradiol, Creteil, France

[5] Hop Paul Brousse, INSERM U258, Villejuif, France

来源：

NEUROLOGY | 2001年 / 56卷 / 11期

关键词：

D O I：

10.1212/WNL.56.11.1593

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case-control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.

引用

页码：1593 / 1595

页数：3

共 10 条

[1] The deletion allele of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment
Amouyel, P
Richard, F
Cottel, D
Amant, C
Codron, V
Helbecque, N
[J]. NEUROSCIENCE LETTERS, 1996, 217 (2-3) : 203 - 205
[2] ANGIOTENSIN CONVERTING ENZYME DENSITY IS INCREASED IN TEMPORAL CORTEX FROM PATIENTS WITH ALZHEIMERS-DISEASE
BARNES, NM
CHENG, CHK
COSTALL, B
NAYLOR, RJ
WILLIAMS, TJ
WISCHIK, CM
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 200 (2-3) : 289 - 292
[3] Vascular risk factors for Alzheimer's disease: An epidemiologic perspective
Breteler, MMB
[J]. NEUROBIOLOGY OF AGING, 2000, 21 (02) : 153 - 160
[4] ANGIOTENSIN-I-CONVERTING ENZYME IN HUMAN CIRCULATING MONONUCLEAR-CELLS - GENETIC-POLYMORPHISM OF EXPRESSION IN LYMPHOCYTES-T
COSTEROUSSE, O
ALLEGRINI, J
LOPEZ, M
ALHENCGELAS, F
[J]. BIOCHEMICAL JOURNAL, 1993, 290 : 33 - 40
[5] Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease
Crawford, F
Abdullah, L
Schinka, J
Suo, ZM
Gold, M
Duara, R
Mullan, M
[J]. NEUROSCIENCE LETTERS, 2000, 280 (03) : 215 - 219
[6] The ACE gene and Alzheimer's disease susceptibility
Narain, Y
Yip, A
Murphy, T
Brayne, C
Easton, D
Evans, JG
Xuereb, J
Cairns, N
Esiri, MM
Furlong, RA
Rubinsztein, DC
[J]. JOURNAL OF MEDICAL GENETICS, 2000, 37 (09) : 695 - 697
[7] Angiotensin-converting enzyme and cardiovascular disease risk
O'Malley, JP
Maslen, CL
Illingworth, DR
[J]. CURRENT OPINION IN LIPIDOLOGY, 1999, 10 (05) : 407 - 415
[8] Angiotensin converting enzyme deletion allele in different kinds of dementia disorders
Palumbo, B
Cadini, D
Nocentini, G
Filipponi, E
Fravolini, ML
Senin, U
[J]. NEUROSCIENCE LETTERS, 1999, 267 (02) : 97 - 100
[9] Effect of the angiotensin I-converting enzyme I/D polymorphism on cognitive decline
Richard, F
Berr, C
Amant, C
Helbecque, N
Amouyel, P
Alpérovitch, A
[J]. NEUROBIOLOGY OF AGING, 2000, 21 (01) : 75 - 80
[10] TIRET L, 1992, AM J HUM GENET, V51, P197

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