Role of nitric oxide in insulin-induced hypothermia in rats

被引：27

作者：

Almeida, MC ^{[1
]}

Branco, LGS ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Morfol Estomatol & Fisiol, BR-14040904 Ribeirao Preto, SP, Brazil

来源：

BRAIN RESEARCH BULLETIN | 2001年 / 54卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

insulin; nitric oxide; body temperature; nitric oxide synthase; hypothermia;

D O I：

10.1016/S0361-9230(00)00423-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hypothermia is a well-known phenomenon which accompanies hypoglycemia in mammals. The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in insulin-induced hypothermia. The body temperature (Tb) of awake, unrestrained rats was measured before and after systemic infusion of insulin (2U.kg(-1).h(-1)), and intracerebroventricular administration of N-G-nitro-(L)-arginine methyl ester (L-NAME, a nonselective NO synthase inhibitor, 200 mug/1 mul). We observed a significant reduction in body temperature after insulin infusion. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, no change in Tb was observed. The data indicate that NO plays a key role in insulin-induced hypothermia. (C) 2001 Elsevier Science Inc.

引用

收藏

页码：49 / 53

页数：5

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