TAMeless traitors: macrophages in cancer progression and metastasis

被引：568

作者：

Aras, Shweta ^{[1
,2
]}

Zaidi, M. Raza ^{[1
,2
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

[2] Temple Univ, Lewis Katz Sch Med, Dept Med Genet & Mol Biochem, Philadelphia, PA 19140 USA

来源：

BRITISH JOURNAL OF CANCER | 2017年 / 117卷 / 11期

基金：

美国国家卫生研究院;

关键词：

tumour-associated macrophages; spectrum polarisation; cancer; invasion; metastasis; immunosuppression; TUMOR-ASSOCIATED MACROPHAGES; EPITHELIAL-MESENCHYMAL TRANSITION; CLASSICALLY ACTIVATED MACROPHAGES; MAMMARY-TUMORS; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; OVARIAN-CANCER; MICROENVIRONMENTAL REGULATION; INFILTRATING MACROPHAGES; PREMETASTATIC NICHE;

D O I：

10.1038/bjc.2017.356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Macrophages are conventionally classified into M1 and M2 subtypes according to their differentiation status and functional role in the immune system. However, accumulating evidence suggests that this binary classification system is insufficient to account for the remarkable plasticity of macrophages that gives rise to an immense diversity of subtypes. This diverse spectrum of macrophage subtypes play critical roles in various homeostatic and immune functions, but remain far from being fully characterised. In addition to their roles in normal physiological conditions, macrophages also play crucial roles in disease conditions such as cancer. In this review, we discuss the roles tumour-associated macrophages (TAMs) play in regulating different steps of tumour progression and metastasis, and the opportunities to target them in the quest for cancer prevention and treatment.

引用

页码：1583 / 1591

页数：9

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