Cytokines and sickness behavior: implications from knockout animal models

被引：44

作者：

Inui, A ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Div Diabet Digest & Kidney Dis, Dept Clin Mol Med,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 09期

关键词：

D O I：

10.1016/S1471-4906(01)01981-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines are key regulators of host defenses mediated by the central nervous system and are important in the development of signs of sickness, such as anorexia and fever. Despite the well-documented redundancy in the cytokine cascade, recent studies with knockout animals have demonstrated successfully considerable functional specificity of cytokines in normal, as well as sickness, behavior.

引用

页码：469 / 473

页数：5

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