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The renin-angiotensin system in diabetic nephropathy: The endothelial connection

被引：17
作者：
Rabelink, TJ
Bakris, GL
机构：
[1] Univ Utrecht, Med Ctr, Dept Hypertens & Nephrol, NL-3508 GA Utrecht, Netherlands
[2] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Hypertens Ctr, Chicago, IL 60612 USA
来源：
MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 06期
关键词：
diabetes; nitric oxide; endothelin; renin-angiotensin system;
D O I：
10.1159/000057399
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years endothelial function has been forwarded a modulator in the pathogenesis of diabetic nephropathy. This review summarizes how an imbalance between endothelium-derived reactive nitrogen species and reactive oxygen species as ell as increased expression of the endotheliumderived peptide endothelin-1 may contribute to loss of renal function in diabetes. In addition, the potentially beneficial effects of blockade of the renin-angiotensin system on this endothelial dysbalance is discussed.
引用
收藏
页码：381 / 388
页数：8
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