学术探索
学术期刊
新闻热点
数据分析
智能评审

The renin-angiotensin system in diabetic nephropathy: The endothelial connection

被引：17
作者：
Rabelink, TJ
Bakris, GL
机构：
[1] Univ Utrecht, Med Ctr, Dept Hypertens & Nephrol, NL-3508 GA Utrecht, Netherlands
[2] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Hypertens Ctr, Chicago, IL 60612 USA
来源：
MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 06期
关键词：
diabetes; nitric oxide; endothelin; renin-angiotensin system;
D O I：
10.1159/000057399
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years endothelial function has been forwarded a modulator in the pathogenesis of diabetic nephropathy. This review summarizes how an imbalance between endothelium-derived reactive nitrogen species and reactive oxygen species as ell as increased expression of the endotheliumderived peptide endothelin-1 may contribute to loss of renal function in diabetes. In addition, the potentially beneficial effects of blockade of the renin-angiotensin system on this endothelial dysbalance is discussed.
引用
收藏
页码：381 / 388
页数：8
相关论文
共 122 条
  • [91] EFFECTS OF ENDOTHELIN-1 ON RENAL-FUNCTION IN HUMANS - IMPLICATIONS FOR PHYSIOLOGY AND PATHOPHYSIOLOGY
    RABELINK, TJ
    KAASJAGER, KAH
    BOER, P
    STROES, EG
    BRAAM, B
    KOOMANS, HA
    [J]. KIDNEY INTERNATIONAL, 1994, 46 (02) : 376 - 381
  • [92] Endothelin in renal pathophysiology: From experimental to therapeutic application
    Rabelink, TJ
    Kaasjager, KAH
    Stroes, ESG
    Koomans, HA
    [J]. KIDNEY INTERNATIONAL, 1996, 50 (06) : 1827 - 1833
  • [93] Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation - Contribution to alterations of vasomotor tone
    Rajagopalan, S
    Kurz, S
    Munzel, T
    Tarpey, M
    Freeman, BA
    Griendling, KK
    Harrison, DG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (08) : 1916 - 1923
  • [94] Role for endothelin-1 in angiotensin II-mediated hypertension
    Rajagopalan, S
    Laursen, JB
    Borthayre, A
    Kurz, S
    Keiser, J
    Haleen, S
    Giaid, A
    Harrison, DG
    [J]. HYPERTENSION, 1997, 30 (01) : 29 - 34
  • [95] Ritter J M, 1996, Blood Press Suppl, V2, P67
  • [96] RuizOrtega M, 1997, J AM SOC NEPHROL, V8, P756
  • [97] RUIZORTEGA M, 1994, J HYPERTENS S4, V12, P51
  • [98] Expression and regulation of endothelial nitric oxide synthase
    Sase, K
    Michel, T
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 1997, 7 (01) : 28 - 37
  • [99] Saxena Uday, 1994, Current Opinion in Lipidology, V5, P316, DOI 10.1097/00041433-199410000-00002
  • [100] Increased renal production of transforming growth factor-beta(1) in patients with type II diabetes
    Sharma, K
    Ziyadeh, FN
    Alzahabi, B
    McGowan, TA
    Kapoor, S
    Kurnik, BRC
    Kurnik, PB
    Weisberg, LS
    [J]. DIABETES, 1997, 46 (05) : 854 - 859
45678910111213