Xanthones-A structural perspective

被引：53

作者：

Gales, L

Damas, AM

机构：

[1] Univ Porto, Inst Biol Mol & Celular, P-4150 Oporto, Portugal

[2] Univ Porto, ICBAS, P-4150 Oporto, Portugal

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 21期

关键词：

xanthone; three-dimensional structure; crystallography;

D O I：

10.2174/092986705774370727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Xanthones, synthesized or isolated from a natural source, display a wide range of biological and pharmacological activities. In a few cases, their chemical characterization has involved the structure elucidation by single crystal X-ray diffraction. The purpose of this review is to assess in detail this three-dimensional structural data, and thus contribute to a better understanding of the molecular mechanisms involved in the different biological activities presented by xanthones.

引用

收藏

页码：2499 / 2515

页数：17

相关论文

共 63 条

[51] Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay [J].

Saraiva, L ;

Fresco, P ;

Pinto, E ;

Kijjoa, A ;

Gonzlaez, MJ ;

Gonçalves, J .

PLANTA MEDICA, 2002, 68 (11) :1039-1041

[52] Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives [J].

Saraiva, L ;

Fresco, P ;

Pinto, E ;

Sousa, E ;

Pinto, M ;

Gonçalves, J .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (10) :3219-3227

[53] 1-hydroxy-2,3,4,7-tetramethoxyxanthone from Swertia Chirayita [J].

Shi, GF ;

Lu, RH ;

Yang, YS ;

Li, CL ;

Yang, AM ;

Cai, LX .

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2004, 60 :O878-O880

[54] STRUCTURE OF 10-[4-(ACETOXY)PHENYL]-10-HYDROXY-9(10H)-ANTHRACENONE [J].

SKRZAT, Z ;

ROSZAK, A .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1986, 42 :1194-1196

[55] STRUCTURAL STUDIES OF POLYCHLORINATED HYDROCARBONS .2. HEXACHLOROXANTHENE AND HEXACHLOROXANTHONE [J].

SODERHOLM, M ;

SONNERSTAM, U ;

NORRESTAM, R ;

PALM, TB .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (NOV15) :3013-3018

[56]

Sousa EP, 2002, HELV CHIM ACTA, V85, P2862, DOI 10.1002/1522-2675(200209)85:9<2862::AID-HLCA2862>3.0.CO

[57]

2-R

[58] XANTHONES OF GENTIANACEAE .3. CRYSTAL AND MOLECULAR STRUCTURE OF 2-HYDROXY-1,3,4,7-TETRAMETHOXYXANTHONE [J].

STOUT, GH ;

LIN, TS ;

SINGH, I .

TETRAHEDRON, 1969, 25 (09) :1975-&

[59] CELEBIXANTHONE - A COMBINED CHEMICAL AND CRYSTALLOGRAPHIC STRUCTURE PROOF [J].

STOUT, GH ;

WELSH, MJ ;

STOUT, VF .

TETRAHEDRON, 1963, 19 (04) :667-&

[60] STRUCTURE OF 6-METHOXY-1-[(4-METHOXYPHENYL)AMINO]XANTHEN-9-ONE [J].

SUDARSANAKUMAR, C ;

SRINIVASAN, S ;

CHANDRASEKHAR, B ;

RAMADAS, SR .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1990, 46 :849-852

← 1 2 3 4 5 6 7 →