Carboxylated magnetic nanoparticles as MRI contrast agents: Relaxation measurements at different field strengths

被引：38

作者：

Jedlovszky-Hajdu, Angela ^{[1
]}

Tombacz, Etelka ^{[2
]}

Banyai, Istvan ^{[3
]}

Babos, Magor ^{[4
]}

Palko, Andras ^{[5
]}

机构：

[1] Semmelweis Univ, Lab Nanochem, Dept Biophys & Radiat Biol, H-1089 Budapest, Hungary

[2] Univ Szeged, Dept Phys Chem & Mat Sci, H-6720 Szeged, Hungary

[3] Univ Debrecen, Dept Colloid & Environm Chem, Debrecen, Hungary

[4] Euromed Diagnost Szeged Ltd, H-6720 Szeged, Hungary

[5] Univ Szeged, Fac Med, Dept Radiol, H-6720 Szeged, Hungary

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2012年 / 324卷 / 19期

关键词：

Magnetic fluid; MR Imaging; Nuclear MR; Iron oxide nanoparticle; IRON-OXIDE NANOPARTICLES; ADSORPTION; PARTICLES;

D O I：

10.1016/j.jmmm.2012.05.031

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

At the moment the biomedical applications of magnetic fluids are the subject of intensive scientific interest. In the present work, magnetite nanoparticles (MNPs) were synthesized and stabilized in aqueous medium with different carboxylic compounds (citric acid (CA), polyacrylic acid (PAA), and sodium oleate (NaOA)), in order to prepare well stabilized magnetic fluids (MFs). The magnetic nanoparticles can be used in the magnetic resonance imaging (MRI) as contrast agents. Magnetic resonance relaxation measurements of the above MFs were performed at different field strengths (i.e., 0.47, 1.5 and 9.4 T) to reveal the field strength dependence of their magnetic responses, and to compare them with that of ferucarbotran, a well-known superparamagnetic contrast agent. The measurements showed characteristic differences between the tested magnetic fluids stabilized by carboxylic compounds and ferucarbotran. It is worthy of note that our magnetic fluids have the highest r(2) relaxivities at the field strength of 1.5 T, where the most of the MRI works in worldwide. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：3173 / 3180

页数：8

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