Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones

被引：75

作者：

Jarvest, RL

Pinto, IL

Ashman, SM

Dabrowski, CE

Fernandez, AV

Jennings, LJ

Lavery, P

Tew, DG

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[2] SmithKline Beecham Pharmaceut, Collegeville, PA USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(99)00004-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

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页码：443 / 448

页数：6

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