Novel, selective mechanism-based inhibitors of the herpes proteases

被引：58

作者：

Pinto, IL ^{[1
]}

West, A ^{[1
]}

Debouck, CM ^{[1
]}

DiLella, AG ^{[1
]}

Gorniak, JG ^{[1
]}

ODonnell, KC ^{[1
]}

OShannessy, DJ ^{[1
]}

Patel, A ^{[1
]}

Jarvest, RL ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00456-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyI oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2467 / 2472

页数：6

共 14 条

[1] STUDIES ON 2-METHYL-4-ARYLMETHYLENE-2-IMIDAZOLIN-5-ONES AND 2-PHENYL-4-ARYLMETHYLENE-2-IMIDAZOLIN-5-ONES AND RELATED-COMPOUNDS [J].

BADR, MZ ;

ELSHERIEF, HAH ;

TADROS, ME .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1982, 55 (07) :2267-2270

[2] ACTION OF DIAZOMETHANE ON (Z/E)-2-METHYL(OR PHENYL)-4-BENZYLIDENE-5(4H)-OXAZOLONES [J].

CATIVIELA, C ;

DEVILLEGAS, MDD ;

MAYORAL, JA ;

MELENDEZ, E .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (08) :1436-1439

[3]

DILANNI CL, 1994, J BIOL CHEM, V269, P12672

[4]

DILELLA AG, 1995, Patent No. 6055

[5] GASTROINTESTINAL CYTOMEGALOVIRUS DISEASE [J].

GOODGAME, RW .

ANNALS OF INTERNAL MEDICINE, 1993, 119 (09) :924-935

[6] INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY DERIVATIVES OF N-HYDROXYSUCCINIMIDE - A STRUCTURE ACTIVITY-RELATIONSHIP STUDY [J].

GROUTAS, WC ;

BRUBAKER, MJ ;

STANGA, MA ;

CASTRISOS, JC ;

CROWLEY, JP ;

SCHATZ, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (07) :1607-1611

[7] C-13 NMR EVIDENCE FOR AN ENZYME-INDUCED LOSSEN REARRANGEMENT IN THE MECHANISM-BASED INACTIVATION OF ALPHA-CHYMOTRYPSIN BY 3-BENZYL-N-((METHYLSULFONYL)OXY)SUCCINIMIDE [J].

GROUTAS, WC ;

STANGA, MA ;

BRUBAKER, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (05) :1931-1932

[8]

JONES TR, 1994, J VIROL, V68, P2742

[9] THE HERPES-SIMPLEX VIRUS-1 GENE ENCODING A PROTEASE ALSO CONTAINS WITHIN ITS CODING DOMAIN THE GENE ENCODING THE MORE ABUNDANT SUBSTRATE [J].

LIU, FY ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1991, 65 (10) :5149-5156

[10] CYCLOPROPYLOGS OF THYRONINE DERIVATIVES [J].

PAGES, RA ;

BURGER, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (03) :435-&

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