Novel, selective mechanism-based inhibitors of the herpes proteases

被引：58

作者：

Pinto, IL ^{[1
]}

West, A ^{[1
]}

Debouck, CM ^{[1
]}

DiLella, AG ^{[1
]}

Gorniak, JG ^{[1
]}

ODonnell, KC ^{[1
]}

OShannessy, DJ ^{[1
]}

Patel, A ^{[1
]}

Jarvest, RL ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00456-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyI oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2467 / 2472

页数：6