Chasing mutations in the epidermal growth factor in lung cancer

被引:24
作者
Dowell, JE [1 ]
Minna, JD
机构
[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA
[3] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA
关键词
D O I
10.1056/NEJMe058033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:830 / 832
页数:3
相关论文
共 6 条
[1]   Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors [J].
Blencke, S ;
Ullrich, A ;
Daub, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (17) :15435-15440
[2]   EGFR mutation and resistance of non-small-cell lung cancer to gefitinib [J].
Kobayashi, S ;
Boggon, TJ ;
Dayaram, T ;
Janne, PA ;
Kocher, O ;
Meyerson, M ;
Johnson, BE ;
Eck, MJ ;
Tenen, DG ;
Halmos, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :786-792
[3]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[4]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[5]   Overriding imatinib resistance with a novel ABL kinase inhibitor [J].
Shah, NP ;
Tran, C ;
Lee, FY ;
Chen, P ;
Norris, D ;
Sawyers, CL .
SCIENCE, 2004, 305 (5682) :399-401
[6]   Cancer: Addiction to oncogenes - The Achilles heal of cancer [J].
Weinstein, IB .
SCIENCE, 2002, 297 (5578) :63-64