γ-H2AX illuminates meiosis

被引：76

作者：

Hunter, N ^{[1
]}

Börner, GV

Lichten, M

Kleckner, N

机构：

[1] Harvard Univ, Cambridge, MA 02138 USA

[2] NCI, Div Basic Sci, Biochem Lab, Bethesda, MD 20892 USA

来源：

NATURE GENETICS | 2001年 / 27卷 / 03期

关键词：

D O I：

10.1038/85781

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The temporal and functional relationships between the DNA events of meiotic recombination and the synaptonemal complex (SC). a meiosis-specific structure formed between homolog axes, are subjects of intense discussion and investigation. A new study provides evidence that initiation of recombination (through programmed double-strand breaks (DSBs)) precedes initiation of SC formation, and further suggests that progression of recombination is required for formation of SC on a region-by-region basis. These conclusions derive from immunocytological analysis of a phosphorylated histone variant. gamma -H2AX, previously found to be characteristic of DSB repair in mitotic cells, and shown here to be recruited for specialized use during meiosis.

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页码：236 / 238

页数：3

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