RANTES promotes growth and survival of human first-trimester forebrain astrocytes

被引：68

作者：

Bakhiet, M ^{[1
]}

Tjernlund, A

Mousa, A

Gad, A

Strömblad, S

Kuziel, WA

Seiger, A

Andersson, J

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, SE-14186 Stockholm, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Div Geriatr Med, SE-14186 Stockholm, Sweden

[3] Huddinge Univ Hosp, Karolinska Inst, Dept Immunol Microbiol & Pathol, Div Pathol, SE-14186 Stockholm, Sweden

[4] Sodertorns Hogskola, Stockholm, Sweden

[5] Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

[6] Univ Texas, Inst Cell & Mol Biol, Austin, TX 78712 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 02期

关键词：

D O I：

10.1038/35055057

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have examined the role of alpha and beta chemokines in the promotion of the ontogenetic development of the brain. RANTES was expressed preferentially in human fetal astrocytes in an age-dependent manner. Astrocytes from 5-week-old brains showed high proliferation and reduced survival, whereas 10-week-old astrocytes exhibited opposite effects. These effects were suppressed by anti-RANTES or anti-RANTES receptor antibodies and were enhanced by recombinant RANTES. RANTES induced tyrosine phosphorylation of several cellular proteins and nuclear translocation of STAT-1 in astrocytes. Interferons (IFN-gamma) was required for RANTES effects because RANTES induced IFN-gamma, and only 10-week-old astrocytes expressed the IFN-gamma receptor. Blocking of IFN-gamma with antibody reversed the effects of RANTES, indicating that cytokine/chemokine networks are critically involved in brain development.

引用

页码：150 / 157

页数：8

共 35 条

[1]

Andjelkovic AV, 1999, GLIA, V28, P225, DOI 10.1002/(SICI)1098-1136(199912)28:3<225::AID-GLIA6>3.3.CO

[2]

2-Y

[3] A new cell enzyme-linked immunosorbent assay demonstrates gamma interferon suppression by beta interferon in multiple sclerosis [J].

Bakhiet, M ;

Özenci, V ;

Withagen, C ;

Mustafa, M ;

Fredrikson, S ;

Link, H .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1999, 6 (03) :415-419

[4]

Bonecchi R, 1999, J IMMUNOL, V162, P474

[5] Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro [J].

Brew, R ;

Erikson, JS ;

West, DC ;

Flanagan, BF ;

Christmas, SE .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1997, 25 (02) :S264-S264

[6] Elevation of the plasma level of RANTES during asthma attacks [J].

Chihara, J ;

Yasuba, H ;

Tsuda, A ;

Urayama, O ;

Saito, N ;

Honda, K ;

Kayaba, H ;

Yamashita, T ;

Kurimoto, F ;

Yamada, H .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (06) :S52-S55

[7] Proliferative effects of CXC chemokines in rat hepatocytes in vitro and in vivo [J].

Colletti, LM ;

Green, M ;

Burdick, MD ;

Kunkel, SL ;

Strieter, RM .

SHOCK, 1998, 10 (04) :248-257

[8] SENSITIVE MESSENGER-RNA DETECTION USING UNFIXED TISSUE - COMBINED RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

DAGERLIND, A ;

FRIBERG, K ;

BEAN, AJ ;

HOKFELT, T .

HISTOCHEMISTRY, 1992, 98 (01) :39-49

[9] STATs and gene regulation [J].

Darnell, JE .

SCIENCE, 1997, 277 (5332) :1630-1635

[10]

Ehrlich LC, 1998, J IMMUNOL, V160, P1944

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