RANTES promotes growth and survival of human first-trimester forebrain astrocytes

被引：68

作者：

Bakhiet, M ^{[1
]}

Tjernlund, A

Mousa, A

Gad, A

Strömblad, S

Kuziel, WA

Seiger, A

Andersson, J

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, SE-14186 Stockholm, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Div Geriatr Med, SE-14186 Stockholm, Sweden

[3] Huddinge Univ Hosp, Karolinska Inst, Dept Immunol Microbiol & Pathol, Div Pathol, SE-14186 Stockholm, Sweden

[4] Sodertorns Hogskola, Stockholm, Sweden

[5] Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

[6] Univ Texas, Inst Cell & Mol Biol, Austin, TX 78712 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 02期

关键词：

D O I：

10.1038/35055057

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have examined the role of alpha and beta chemokines in the promotion of the ontogenetic development of the brain. RANTES was expressed preferentially in human fetal astrocytes in an age-dependent manner. Astrocytes from 5-week-old brains showed high proliferation and reduced survival, whereas 10-week-old astrocytes exhibited opposite effects. These effects were suppressed by anti-RANTES or anti-RANTES receptor antibodies and were enhanced by recombinant RANTES. RANTES induced tyrosine phosphorylation of several cellular proteins and nuclear translocation of STAT-1 in astrocytes. Interferons (IFN-gamma) was required for RANTES effects because RANTES induced IFN-gamma, and only 10-week-old astrocytes expressed the IFN-gamma receptor. Blocking of IFN-gamma with antibody reversed the effects of RANTES, indicating that cytokine/chemokine networks are critically involved in brain development.

引用

页码：150 / 157

页数：8

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