Upgraded role of autophagy in colorectal carcinomas

被引：17

作者：

Koustas, Evangelos ^{[1
]}

Sarantis, Panagiotis ^{[1
]}

Papavassiliou, Athanassios G. ^{[1
]}

Karamouzis, Michalis V. ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Div Mol Oncol, Athens 11527, Greece

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2018年 / 10卷 / 11期

关键词：

Autophagy; Tumorigenesis; Clinical trials; Autophagy inhibitors; Colorectal cancer; CANCER; EGFR;

D O I：

10.4251/wjgo.v10.i11.367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy is a basic catabolic process closely associated with degradation of cellular components. The role of autophagy in colorectal cancer (CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorigenesis by isolation of damaged organelles or as cytoprotective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3K/AKT/mTOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients.

引用

页码：367 / 369

页数：3

共 11 条

[1]

Autophagy in colorectal cancer: An important switch from physiology to pathology [J].

Burada, Florin ;

Nicoli, Elena Raluca ;

Ciurea, Marius Eugen ;

Uscatu, Daniel Constantin ;

Ioana, Mihai ;

Gheonea, Dan Ionut .

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2015, 7 (11) :271-284

[2]

The Autophagy Machinery: A New Player in Chemotactic Cell Migration [J].

Coly, Pierre-Michael ;

Gandolfo, Pierrick ;

Castel, Helene ;

Morin, Fabrice .

FRONTIERS IN NEUROSCIENCE, 2017, 11

[3]

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis [J].

Guo, Jessie Yanxiang ;

Chen, Hsin-Yi ;

Mathew, Robin ;

Fan, Jing ;

Strohecker, Anne M. ;

Karsli-Uzunbas, Gizem ;

Kamphorst, Jurre J. ;

Chen, Guanghua ;

Lemons, Johanna M. S. ;

Karantza, Vassiliki ;

Coller, Hilary A. ;

DiPaola, Robert S. ;

Gelinas, Celine ;

Rabinowitz, Joshua D. ;

White, Eileen .

GENES & DEVELOPMENT, 2011, 25 (05) :460-470

[4]

Role of autophagy in cancer - Management of metabolic stress [J].

Jin, Shengkan ;

White, Eileen .

AUTOPHAGY, 2007, 3 (01) :28-31

[5]

Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer [J].

Koustas, Evangelos ;

Karamouzis, Michalis V. ;

Mihailidou, Chrysovalantou ;

Schizas, Dimitrios ;

Papavassiliou, Athanasios G. .

CANCER LETTERS, 2017, 396 :94-102

[6]

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy [J].

Marinkovic, Mija ;

Sprung, Matilda ;

Buljubasic, Maja ;

Novak, Ivana .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018

[7]

Interplay between apoptosis and autophagy in colorectal cancer [J].

Qian, Hao-Ran ;

Shi, Zhao-Qi ;

Zhu, He-Pan ;

Gu, Li-Hu ;

Wang, Xian-Fa ;

Yang, Yi .

ONCOTARGET, 2017, 8 (37) :62759-62768

[8]

Cancer Statistics, 2014 [J].

Siegel, Rebecca ;

Ma, Jiemin ;

Zou, Zhaohui ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (01) :9-29

[9]

Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications [J].

Tan, Xiaojun ;

Lambert, Paul F. ;

Rapraeger, Alan C. ;

Anderson, Richard A. .

TRENDS IN CELL BIOLOGY, 2016, 26 (05) :352-366

[10]

The role of autophagy induced by tumor microenvironment in different cells and stages of cancer [J].

Yang, Xue ;

Yu, Dan-Dan ;

Yan, Fei ;

Jing, Ying-Ying ;

Han, Zhi-Peng ;

Sun, Kai ;

Liang, Lei ;

Hou, Jing ;

Wei, Li-Xin .

CELL AND BIOSCIENCE, 2015, 5

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