Carcinogenicity of food mutagens

被引:46
作者
Sugimura, T
Nagao, M
Wakabayashi, K
机构
关键词
mutagens in food; carcinogens in food; exogenous mutagens; endogenous mutagens; heterocyclic amines; risk; cancer prevention;
D O I
10.2307/3432798
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Cancer cells are produced by the accumulation of genetic alterations in somatic cells. Those genetic alterations are produced by xenobiotics, which enter the human body from the environment, and by autobiotics, which are produced in the human body. Food contains many different types of xenobiotic mutagens/carcinogens and tumor promoters. Food can influence the formation of autobiotic mutagens/carcinogens and give rise to tumor-promoting conditions. In spite of this, it can also contain many antimutagenic, anticarcinogenic, and antitumor-promoting substances. Carcinogenic risk and anticarcinogenic efficacy are hard to express quantitatively; however, holistic approaches that are designed to improve lifestyle are realistic for cancer prevention.
引用
收藏
页码:429 / 433
页数:5
相关论文
共 49 条
[21]  
MURAKOSHI M, 1992, CANCER RES, V52, P6583
[22]  
OKAMOTO T, 1989, JPN J CANCER RES, V80, P191
[23]   HELICOBACTER-PYLORI INFECTION AND THE RISK OF GASTRIC-CARCINOMA [J].
PARSONNET, J ;
FRIEDMAN, GD ;
VANDERSTEEN, DP ;
CHANG, Y ;
VOGELMAN, JH ;
ORENTREICH, N ;
SIBLEY, RK .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1127-1131
[24]  
PETREIRA MA, 1994, CARCINOGENESIS, V15, P1049
[25]   EFFECT OF INDOMETHACIN ON INTESTINAL TUMORS INDUCED IN RATS BY THE ACETATE DERIVATIVE OF DIMETHYLNITROSAMINE [J].
POLLARD, M ;
LUCKERT, PH .
SCIENCE, 1981, 214 (4520) :558-559
[26]   INHIBITORY EFFECT OF ASPIRIN ON AZOXYMETHANE-INDUCED COLON CARCINOGENESIS IN F344 RATS [J].
REDDY, BS ;
RAO, CV ;
RIVENSON, A ;
KELLOFF, G .
CARCINOGENESIS, 1993, 14 (08) :1493-1497
[27]  
Saito D, 1980, Teratog Carcinog Mutagen, V1, P213
[28]   CANCER CHEMOPREVENTION BY SUPPLEMENTAL CAROTENOIDS IN ANIMALS AND HUMANS [J].
SANTAMARIA, L ;
BIANCHI, A .
PREVENTIVE MEDICINE, 1989, 18 (05) :603-623
[29]  
SCANLAN RA, 1983, CANCER RES, V43, P2435
[30]  
SPALDING JW, 1988, NATL TOXICOL PROGRAM, V331, P5