Cloning and characterization of TNKL, a member of tankyrase gene family

被引：35

作者：

Kuimov, AN

Kuprash, DV

Petrov, VN

Vdovichenko, KK

Scanlan, MJ

Jongeneel, CV

Lagarkova, MA

Nedospasov, SA ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Ctr Mol Med, Lab Mol Immunol, Moscow 119899, Russia

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119899, Russia

[3] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 117984, Russia

[4] Mem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10021 USA

[5] Ludwig Inst Canc Res, Off Informat Technol, CH-1066 Epalinges, Switzerland

来源：

GENES AND IMMUNITY | 2001年 / 2卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

SEREX; telomeres; antibodies; ankyrin; tankyrase;

D O I：

10.1038/sj.gene.6363722

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl. encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282. 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis. Genes and Immunity (2001) 2, 52-55.

引用

页码：52 / 55

页数：4

共 17 条

[1] Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas [J].