Interactions within the Hand Representation in Primary Somatosensory Cortex of Primates

被引:27
作者
Lipton, Michael L. [1 ,2 ,3 ,4 ,5 ]
Liszewski, Mark C. [9 ]
O'Connell, M. Noelle [6 ]
Mills, Aimee [6 ]
Smiley, John F. [6 ]
Branch, Craig A. [1 ,2 ]
Isler, Joseph R. [7 ]
Schroeder, Charles E. [6 ,8 ]
机构
[1] Albert Einstein Coll Med, Gruss Magnet Resonance Ctr, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Radiol, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10461 USA
[4] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA
[5] Montefiore Med Ctr, Dept Radiol, Bronx, NY 10467 USA
[6] Nathan S Kline Inst Psychiat Res, Program Cognit Neurosci & Schizophrenia, Orangeburg, NY 10962 USA
[7] Columbia Univ, Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA
[8] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[9] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
SOURCE-DENSITY ANALYSIS; FUNCTIONAL-ORGANIZATION; EVOKED-POTENTIALS; SQUIRREL-MONKEYS; MACAQUE MONKEYS; AREA; 3B; SPATIAL INTEGRATION; POSTCENTRAL GYRUS; RECEPTIVE-FIELDS; AUDITORY-CORTEX;
D O I
10.1523/JNEUROSCI.4765-09.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous studies indicate that primary somatosensory cortical area 3b in macaques contains a somatotopic map of the hand, encompassing representations of each digit. However, numerous observations including recent findings in anesthetized New World monkeys indicate that that the digit representations within the map are not discrete. We assessed the generality and spatial extent of these effects in awake macaques. We show that, within a given digit representation, (1) there is response to stimulation of all other digits tested, extending across most or all of the digit map, and (2) response to stimulation of the locally preferred digit is modulated by concurrent stimulation of each of the other digits. Control experiments rule out effects of attention and mechanical spread of stimulation. We thus confirm that, even at the first level of somatosensory cortical processing, inputs from potentially all of the digits frame the context within which the input to a single digit is represented.
引用
收藏
页码:15895 / 15903
页数:9
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