Do all of human midbrain tyrosine hydroxylase neurons synthesize dopamine?

被引：30

作者：

Ikemoto, K ^{[1
]}

Nagatsu, I

Nishimura, A

Nishi, K

Arai, R

机构：

[1] Fujita Heath Univ, Sch Med, Dept Anat, Toyoake, Aichi 4701192, Japan

[2] Shiga Univ Med Sci, Dept Legal Med, Otsu, Shiga 5202121, Japan

来源：

BRAIN RESEARCH | 1998年 / 805卷 / 1-2期

关键词：

human; substantia nigra; ventral tegmental area; aromatic L-amino acid decarboxylase; tyrosine hydroxylase; dopamine; immunohistochemistry;

D O I：

10.1016/S0006-8993(98)00661-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether all of human midbrain tyrosine hydroxylase (TH) neurons substantially synthesize dopamine (DA) using dual labeling immunohistochemical technique of TH and aromatic L-amino acid decarboxylase (AADC). In the substantia nigra, besides many neurons doubly stained for TH and AADC, neurons stained only for TH and only for AADC (D-neurons [C.B. Jaeger, D.A. Ruggiero, V.R. Albert, T.H. Joh, D.J. Reis, Immunocytochemical localization of aromatic L-amino acid decarboxylase, in: A. Bjorklund, T. Hokfelt (Eds.), Handbook of Chemical Neuroanatomy, Classical Transmitters in the CNS, Vol. 2, Part 1, Elsevier, Amsterdam, 1984, pp. 387-408.]) were identified. In the ventral tegmental area, dually labeled neurons and TH-only-positive neurons were found. It is indicated that the number of midbrain TH neurons does not reflect the exact number of DA neurons. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：255 / 258

页数：4

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