Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics

被引:71
作者
Zhang, Xiang Yang
Tan, Yun Long
Zhou, Dong Feng
Cao, Lian Yuan
Wu, Gui Ying
Xu, Qi
Shen, Yan
Halle, Colin N.
Kosten, Therese A.
Kosten, Thomas R.
机构
[1] Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
[2] Peking Univ, Inst Metal Hlth, Beijing 100083, Peoples R China
[3] Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
[4] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
[5] Peking Union Med, Beijing 100005, Peoples R China
关键词
schizophrenia; antipsychotic; weight gain; BDNF; serum; sex difference;
D O I
10.1016/j.jpsychires.2006.08.007
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Several lines of evidence suggest that central brain-derived neurotrophic factor (BDNF) modulates food intake, metabolism, and increases in body weight. Reports have also shown that serum BDNF is altered in schizophrenic patients treated with antipsychotics. This study aimed to determine if there was a relationship between BDNF and antipsychotic-induced weight gain in patients with chronic schizophrenia. Serum BDNF was measured in 124 schizophrenia patients chronically treated with clozapine (n = 57), risperidone (n = 23) or typical antipsychotics (n = 44) and 50 healthy control subjects. To further assess group differences in serum BDNF, additional analyses were performed in a subset of patients and controls individually matched for body mass index (BMI). BDNF levels were lower in patients with schizophrenia than normal controls. However, this difference was not present when controlling for current BMI. In the individually BMI-matched sample, no differences in serum BDNF levels were observed in schizophrenic patients compared to BMI-matched healthy controls. BDNF levels negatively correlated with BMI gain in female but not in male patients when gender was considered. Antipsychotic class exerted differential effects over BDNF levels and BMI gain. Our findings suggest that decreased BDNF levels may be associated with weight gain in female schizophrenic patients on long-term antipsychotic treatment. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码:997 / 1004
页数:8
相关论文
共 53 条
[41]   Behavioural treatment of childhood and adolescent obesity [J].
Robinson, TN .
INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (Suppl 2) :S52-S57
[42]   Brain-derived neurotrophic factor and antidepressant activity [J].
Russo-Neustadt, AA ;
Chen, MJ .
CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (12) :1495-1510
[43]   Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls [J].
Shimizu, E ;
Hashimoto, K ;
Watanabe, H ;
Komatsu, N ;
Okamura, N ;
Koike, K ;
Shinoda, N ;
Nakazato, M ;
Kumakiri, C ;
Okada, S ;
Iyo, M .
NEUROSCIENCE LETTERS, 2003, 351 (02) :111-114
[44]   The implications of weight changes with antipsychotic treatment [J].
Sussman, N .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (03) :S21-S26
[45]  
Sussman N, 2001, J CLIN PSYCHIAT, V62, P5
[46]   Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements [J].
Tan, YL ;
Zhou, DF ;
Zhang, XY .
SCHIZOPHRENIA RESEARCH, 2005, 74 (2-3) :263-270
[47]   Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics [J].
Tan, YL ;
Zhou, DF ;
Cao, LY ;
Zou, YZ ;
Zhang, XY .
NEUROSCIENCE LETTERS, 2005, 382 (1-2) :27-32
[48]   Atypical antipsychotics and weight gain - a systematic review [J].
Taylor, DM ;
McAskill, R .
ACTA PSYCHIATRICA SCANDINAVICA, 2000, 101 (06) :416-432
[49]   NEUROTROPHINS AND NEURONAL PLASTICITY [J].
THOENEN, H .
SCIENCE, 1995, 270 (5236) :593-598
[50]   Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Leprdb/leprdb mice [J].
Tonra, JR ;
Ono, M ;
Liu, XC ;
Garcia, K ;
Jackson, C ;
Yancopoulos, GD ;
Wiegand, SJ ;
Wong, V .
DIABETES, 1999, 48 (03) :588-594