Decreased serum amyloid β1-42 autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid β1-42 peptide

被引:62
作者
Brettschneider, S
Morgenthaler, NG
Teipel, SJ
Fischer-Schulz, C
Bürger, K
Dodel, R
Du, YS
Möller, HJ
Bergmann, A
Hampel, H
机构
[1] Univ Munich, Dept Psychiat, Alzheimer Mem Ctr, D-80336 Munich, Germany
[2] Univ Munich, Dept Psychiat, Geriatr Psychiat Branch, D-80336 Munich, Germany
[3] Univ Munich, Dept Psychiat, Dementia Res Sect, D-80336 Munich, Germany
[4] Univ Munich, Dept Psychiat, Memory Clin, D-80336 Munich, Germany
[5] BRAHMS AG, Ctr Biotechnol, Henningsdorf Berlin, Germany
[6] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany
[7] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
关键词
Alzheimer's disease; A beta autoantibodies; biomarkers; cerebrospinal fluid (CSF); diagnosis; bioassay;
D O I
10.1016/j.biopsych.2004.12.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Autoantibodies against amyloid beta (A beta) peptide found in patients with Alzheimer's disease (AD) also occur naturally in the general population independently of the cognitive status. Methods: We compared serum A beta(1-42) autoantibody levels (A beta(1-42)-AL) of 96 AD patients and 30 healthy elderly control subjects (HC), assessing their diagnostic value for AD with a newly developed immunoprecipitation assaywith radiolabeled A beta(1-42) peptide. Results: We found a highly significant decrease of A beta(1-42)-AL in AD patients (p =.001) independently of age, cognitive status, and apolipoprotein E epsilon 4 carrier status. Amyloid beta(1-42) autoantibody levels were correlated with gender in AD, with a higher level occurring in women. When A beta(1-42) autoantibody sensitivity (specificity) was set > 80%, specificity (sensitivity) was below 50% to correctly allocate patients and healthy control subjects. Conclusions: Our data indicate a potentially pathophysiologic decrease of serum. A beta(1-42) antibodies in AD. Amyloid beta(1-42) antibodies in the serum alone, however, seem not to be useful as a diagnostic marker of AD.
引用
收藏
页码:813 / 816
页数:4
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