Boundary formation in Drosophila wing:: Notch activity attenuated by the POU protein Nubbin

被引：57

作者：

Neumann, CJ ^{[1
]}

Cohen, SM ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

SCIENCE | 1998年 / 281卷 / 5375期

关键词：

D O I：

10.1126/science.281.5375.409

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell interactions mediated by Notch-family receptors have been implicated in the specification of tissue boundaries in vertebrate and insect development, Although Notch Ligands are often widely expressed, tightly Localized activation of Notch is critical for the formation of sharp boundaries. Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing. Nubbin represses Notch-dependent target genes and sets a threshold for Notch activity that defines the spatial domain of boundary-specific gene expression.

引用

收藏

页码：409 / 413

页数：5

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