Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers

被引：361

作者：

Dunnenberger, Henry M. ^{[1
]}

Crews, Kristine R. ^{[1
]}

Hoffman, James M. ^{[1
]}

Caudle, Kelly E. ^{[1
]}

Broeckel, Ulrich ^{[3
]}

Howard, Scott C. ^{[2
]}

Hunkler, Robert J. ^{[4
]}

Klein, Teri E. ^{[5
]}

Evans, William E. ^{[1
]}

Relling, Mary V. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[3] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[4] IMS Hlth, Plymouth Meeting, PA 19462 USA

[5] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷

关键词：

pharmacogenomics; precision medicine; individualized medicine; personalized medicine; clinical decision support; prediction in pharmacology; THIOPURINE METHYLTRANSFERASE GENOTYPE; CONSORTIUM CPIC GUIDELINE; HLA-B GENOTYPE; PERSONALIZED MEDICINE; GENOMIC MEDICINE; CYP2C19; GENOTYPE; VKORC1; GENOTYPES; CODEINE THERAPY; CHALLENGES; INTEGRATION;

D O I：

10.1146/annurev-pharmtox-010814-124835

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Although the field of pharmacogenetics has existed for decades, practioners have been slow to implement pharmacogenetic testing in clinical care. Numerous publications describe the barriers to clinical implementation of pharmacogenetics. Recently, several freely available resources have been developed to help address these barriers. In this review, we discuss current programs that use preemptive genotyping to optimize the pharmacotherapy of patients. Array-based preemptive testing includes a large number of relevant pharmacogenes that impact multiple high-risk drugs. Using a preemptive approach allows genotyping results to be available prior to any prescribing decision so that genomic variation may be considered as an inherent patient characteristic in the planning of therapy. This review describes the common elements among programs that have implemented preemptive genotyping and highlights key processes for implementation, including clinical decision support.

引用

页码：89 / +

页数：7

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